Potentiating Effect of 1, 2 - Diazole a Plant Alkaloid on Carrageenan and Formalin Induced Paw Edema in Experimental Mice

Inflammation is a response to acute tissue damage due to physical injury, infection, exposure to toxins and ischemic injury. The persistent inflammatory responses in or around developing neoplasm regulate many aspects of tumor progression. Natural plant based alkaloids are often have greater pharmacological effects and are used as medications as local anesthetic, stimulant, analgesic, anti-bacterial, anticancer, anti-arhythmia, anti-asthma and anti-malarial drug. In the present study, the anti-inflammation activity of 1,2 diazole (pyrazole) a plant alkaloid was examined. In the carrageenan induced mice paw edema model, 1,2 diazole (pyrazole) a plant alkaloid showed significant inhibitory effect on the edema formation. Inflammation induced by formalin results from cell damage, which provokes the production of endogenous mediators such as, histamine, serotonin, prostaglandins and bradykinin. It is then be known from these results that 1,2 diazole (pyrazole) interfere with these inflammatory mediators. Moreover, the high presence of this compound in natural marine mangrove Rhizophora apiculata (R.apiculata) plant extract added advantage as natural source so that this alkaloid can be easily available and with efficient and potential pharmacological properties to treat variety of diseases without any adverse effect.